PUBLICATIONS
The temporal dynamics of Arc expression regulate cognitive flexibility
Wall M, Collins D, Chery S, Allen Z, Pastuzyn ED, George A, Nikolova V, Moy S, Philpot B, Shepherd JD, Müller J, Ehlers M, Mabb A, Corrêa S (2018). Neuron, 6:124-1132.e7.
Arc - an endogenous neuronal retrovirus?
Shepherd JD (2018). Seminars in Cell & Developmental Biology, 77:73-78.
The neuronal gene Arc encodes a repurposed retrotransposon gag protein that mediates intercellular RNA transfer
Pastuzyn ED, Day CE, Kearns RB, Kyrke-Smith M, Taibi AV, McCormick J, Yoder N, Belnap DM, Erlendsson S, Morado DR, Briggs JAG, Feschotte C, Shepherd JD (2018). Cell, 172:1-2.
Activity-dependent Arc expression and homeostatic synaptic plasticity are altered in neurons from a mouse model of Angelman syndrome
Pastuzyn ED, Shepherd JD (2017). Frontiers in Molecular Neuroscience, 10:234.
Arc restores juvenile plasticity in adult mouse visual cortex
Jenks KR, Kim T, Pastuzyn ED, Okuno H, Taibi AV, Bito H, Bear MF, Shepherd JD (2017). Proc Natl Acad Sci, 114(34):9182-9187.
Deep-brain imaging via epi-fluorescence computational cannula microscopy
Kim G, Nagarajan N, Pastuzyn E, Jenks KR, Capecchi M, Shepherd JD, Menon R (2017). Scientific Reports, 7, 44791.
Arc: building a bridge from viruses to memory
Day C, Shepherd JD (2015). Biochemical Journal, 469(1):e1-3.
Imaging activity in neurons and glia with a Polr2a-based and cre-dependent GCaMP5G-IRES-tdTomato reporter mouse
Gee JM, Smith NA, Fernandez FR, Economo MN, Brunert D, Rothermel M, Morris SC, Talbot A, Palumbos S, Ichida JM, Shepherd JD, West PJ, Wachowiak M, Capecchi MR, Wilcox KS, White JA, Tvrdik P (2014). Neuron, 83(5):1058-72.
The role of ionotropic glutamate receptors in childhood neurodevelopmental disorders: autism spectrum disorders and fragile X syndrome
Uzunova G, Hollander E, Shepherd JD (2014). Current Neuropharmacology, 12(1):71-98.
Memory, plasticity, and sleep – a role for calcium permeable AMPA receptors?
Shepherd JD (2012). Frontiers in Molecular Neuroscience, 5:49.
Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation
Wu J, Petralia RS, Kurushima H, Patel H, Jung M, Volk L, Chowdhury S, Shepherd JD, Dehoff M, Li Y, Kuhl D, Huganir RL, Price DL, Scannevin R, Troncoso JC, Wong PC, Worley PF (2011). Cell, 147(3):615-628.
New views of Arc, a master regulator of synaptic plasticity
Shepherd JD and Bear MF (2011). Nature Neuroscience, 14(3): 279–284.
SRF binding to SRE 6.9 in the Arc promoter is essential for the late phase of LTD in cultured Purkinje cells
Smith-Hicks C, Xiao B, Deng R, Ji Y, Zhao X, Shepherd JD, Posern G, Kuhl D, Huganir RL, Ginty DD, Worley PF, Linden DJ (2010). Nature Neuroscience, 13(9):1082-1089.
Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation
It all begins with an idea.
McCurry C, Shepherd JD, Tropea D, Wang K, Bear MF, Sur M (2010). Nature Neuroscience, 13(4):450-7.
Eukaryotic elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc essential for mGluR-LTD
It all begins with an idea.
Park S, Park JM, Kim S, Kim JA, Shepherd JD, Smith-Hicks CL, Chowdhury S, Kaufmann W, Kuhl D, Ryazanov AG, Huganir RL, Linden DJ, Worley PF (2008). Neuron, 59(1):70-83.
The cell biology of synaptic plasticity: AMPA receptor trafficking
It all begins with an idea.
Shepherd JD, Huganir RL (2007). Annual Review of Cell and Developmental Biology, Vol. 23:613-643.
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
It all begins with an idea.
Chowdhury S, Shepherd JD, Ojuno H, Lyford G, Petralia R, Plath N, Kuhl D, Huganir RL, Worley PF (2006). Neuron, 52(3):445-59.
Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors
It all begins with an idea.
Shepherd JD, Rumbaugh G, Wu J, Chowdhury S, Plath N, Kuhl D, Huganir RL, Worley PF (2006). Neuron, 52(3):475-84.
Triple-transgenic model of Alzheimer’s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
It all begins with an idea.
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003). Neuron, 39(3):409-21.